| 21-10-2021 02:00 | Charleston - Los Angeles Galaxy II | MS 2 | 3,15 | 1,98 |
| 21-10-2021 05:00 | Portland Timbers - Vancouver Whitecaps | MS 2 | 3,9 | 3 |
| 21-10-2021 18:00 | Letonya (K) - K.Makedonya Cum. (K) | MS 2 | 3,95 | 3,05 |
| 21-10-2021 23:00 | Metropolitan - Lala FC | MS 1 | 1,56 | 1,21 |
| 21-10-2021 19:45 | Vitesse - Tottenham | MS 1 | 3,6 | 2,8 |
| 21-10-2021 18:00 | Türkiye (K) - Bulgaristan (K) | MS 1 | 1,77 | 1,4 |
| 21-10-2021 18:30 | FC Pro Vercelli 1892 - AS Giana Erminio | MS 2 | 3,85 | 3,1 |
| 21-10-2021 03:30 | Paranaense - Flamengo | MS 1 | 4 | 3,25 |
| 21-10-2021 03:00 | Cuiaba - Brasiliense | MS 2 | 2,25 | 1,83 |
| 21-10-2021 01:30 | CS Deportivo Pereira - Deportes Tol | MS 2 | 2,2 | 1,79 |
| 21-10-2021 05:05 | Cimarrones De Sonora - Tlaxcala FC | MS 1 | 1,89 | 1,57 |
| 21-10-2021 03:30 | Paranaense - Flamengo | MS 0 | 3,25 | 2,7 |
| 21-10-2021 02:30 | Inter Miami CF - Toronto FC | MS 2 | 3 | 2,5 |
| 21-10-2021 04:00 | Real Esteli - Juventus FC | MS 1 | 1,55 | 1,3 |
| 21-10-2021 04:00 | CD Aguila - Metapan | MS 2 | 4,8 | 4,1 |
| 21-10-2021 02:00 | New York Red Bulls II - Loudoun United | MS 1 | 1,6 | 1,37 |
| 21-10-2021 05:00 | Tacoma Defiance - Oakland Roots SC | MS 1 | 2,1 | 1,8 |
| 21-10-2021 02:30 | Tampa Bay - Miami | MS 2 | 4,2 | 3,65 |
| 21-10-2021 19:45 | Rapid Wien - Dinamo Zagreb | MS 2 | 2,36 | 2,06 |
| 21-10-2021 03:30 | Nashville SC - Columbus Crew | MS 0 | 3,3 | 2,9 |
| 21-10-2021 03:15 | Boca Juniors - Godoy Cruz | MS 1 | 1,61 | 1,42 |
| 21-10-2021 18:00 | Letonya (K) - K.Makedonya Cum. (K) | MS 0 | 3,4 | 3 |
| 21-10-2021 02:30 | FC Cincinnati - Chicago Fire | MS 2 | 2,41 | 2,13 |
| 21-10-2021 04:00 | El Paso Loc - Austin Bold | MS 2 | 4,5 | 4 |
| 21-10-2021 22:00 | Mirandes - Girona | MS 2 | 2,55 | 2,28 |
| 21-10-2021 02:00 | Atletico Ottawa - Valour FC | MS 2 | 2,75 | 2,46 |
| 21-10-2021 04:00 | CD Aguila - Metapan | MS 0 | 3,8 | 3,4 |
| 21-10-2021 03:30 | Atletico Mineiro - Fortaleza CE | MS 0 | 3,35 | 3 |
| 21-10-2021 19:00 | Stomil Ols. - P. Bielsko | MS 1 | 3,4 | 3,05 |
| 21-10-2021 20:00 | Zaragoza - SD Ponferradina | MS 1 | 1,85 | 1,66 |
| 21-10-2021 03:00 | Minnesota United - Philadelphia Union | MS 2 | 2,95 | 2,65 |
| 21-10-2021 05:00 | Tigres - CF Pachuca | MS 1 | 1,88 | 1,69 |
| 21-10-2021 04:00 | New Mexico - San Antonio | MS 2 | 2,6 | 2,34 |
| 21-10-2021 02:30 | Atletico Palmaflor Vinto - Independiente Petrolero | MS 0 | 3,15 | 2,85 |
| 21-10-2021 03:05 | Tampico Madero - Atlante FC | MS 0 | 2,85 | 2,6 |
| 21-10-2021 22:00 | Eintracht Frankfurt - Olympiacos | MS 2 | 3,6 | 3,3 |
| 21-10-2021 03:00 | Club Leon - Pumas Unam | MS 2 | 4,8 | 4,4 |
| 21-10-2021 19:45 | Ludogorets - Braga | MS 1 | 3,1 | 2,85 |
| 22-10-2021 00:30 | U. Chile - Palestino | MS 2 | 2,49 | 2,29 |
| 21-10-2021 02:30 | Orlando City - Montreal Impact | MS 0 | 3,25 | 3 |
| 21-10-2021 05:00 | Portland Timbers - Vancouver Whitecaps | MS 0 | 3,3 | 3,05 |
| 21-10-2021 19:45 | Vitesse - Tottenham | MS 0 | 3,4 | 3,15 |
| 21-10-2021 17:30 | FK Napredak Krusevac - Novi Pazar | MS 2 | 4,1 | 3,8 |
| 21-10-2021 03:00 | Union Omaha SC - Forward Ma | MS 0 | 2,75 | 2,55 |
| 21-10-2021 04:00 | Colorado Rapids - Seattle Sounders | MS 1 | 1,85 | 1,72 |
| 21-10-2021 02:30 | SOL De Mayo - Deportivo Madryn | MS 0 | 2,6 | 2,42 |
| 21-10-2021 20:00 | AL Tai - Ahli Saudi | MS 2 | 2,06 | 1,92 |
| 21-10-2021 19:30 | AL Wakrah - AL Duhail SC | MS 2 | 1,33 | 1,24 |
| 21-10-2021 22:00 | Sturm Graz - Real Sociedad | MS 1 | 4,5 | 4,2 |
| 21-10-2021 18:30 | FC Pro Vercelli 1892 - AS Giana Erminio | MS 0 | 3 | 2,8 |
| 21-10-2021 22:00 | Basel - Omonia | MS 1 | 1,42 | 1,33 |
| 21-10-2021 20:00 | Portekiz (K) - Sırbistan (K) | MS 1 | 1,45 | 1,36 |
| 21-10-2021 19:45 | Fenerbahçe - Antwerp | MS 2 | 4,15 | 3,9 |
| 22-10-2021 01:00 | CD Tapatio - CSD Dorados Sinaloa | MS 2 | 2,17 | 2,04 |
| 21-10-2021 04:00 | El Paso Loc - Austin Bold | MS 0 | 3,35 | 3,15 |
| 21-10-2021 22:00 | Real Oviedo - CF Burgos | MS 1 | 1,87 | 1,76 |
| 21-10-2021 02:30 | Tampa Bay - Miami | MS 0 | 3,4 | 3,2 |
| 21-10-2021 17:55 | AL Batin FC - AL Fayha FC | MS 1 | 2,23 | 2,1 |
| 21-10-2021 19:45 | Midtjylland - Kızıl Yıldız | MS 2 | 2,65 | 2,5 |
| 21-10-2021 03:00 | Tulsa Roughnecks - Atlanta United 2 | MS 1 | 1,6 | 1,51 |
| 21-10-2021 22:00 | CSKA Sofya - Zory Luhansk | MS 1 | 1,97 | 1,86 |
| 21-10-2021 19:45 | Fenerbahçe - Antwerp | MS 0 | 3,6 | 3,4 |
| 21-10-2021 05:06 | XolosTijuana - Guadalajara Chivas | MS 0 | 2,7 | 2,55 |
| 21-10-2021 03:00 | Everton DV - Huachipato | MS 0 | 2,75 | 2,6 |
| 21-10-2021 16:15 | PFK Metallurg Bekabad - FK Agmk | MS 1 | 2,8 | 2,65 |
| 21-10-2021 02:00 | CD Walter Ferretti - ART Municipal Jalapa | MS 1 | 1,53 | 1,45 |
| 21-10-2021 03:00 | Union Omaha SC - Forward Ma | MS 1 | 1,55 | 1,47 |
| 21-10-2021 22:00 | Rangers - Brondby | MS 1 | 1,36 | 1,29 |
| 21-10-2021 19:45 | Maccabi Hayfa - Slavia Prag | MS 2 | 2 | 1,9 |
| 21-10-2021 02:30 | Atlanta United - New York City | MS 0 | 3 | 2,85 |
| 21-10-2021 22:00 | Lokomotiv Moskova - Galatasaray | MS 2 | 2,63 | 2,5 |
| 21-10-2021 03:00 | Minnesota United - Philadelphia Union | MS 0 | 3,1 | 2,95 |
| 21-10-2021 19:45 | Real Betis - B. Leverkusen | MS 1 | 2,08 | 1,98 |
| 21-10-2021 22:00 | Sparta Prag - Lyon | MS 1 | 3,15 | 3 |
| 21-10-2021 19:45 | Karabağ - K Almaty | MS 2 | 4,2 | 4 |
| 21-10-2021 03:00 | FC Dallas - Los Angeles FC | MS 2 | 2,19 | 2,09 |
| 21-10-2021 04:15 | Alianza FC - AD Chalatenango | MS 0 | 4,4 | 4,2 |
| 21-10-2021 05:30 | San Jose Earthquakes - Austin FC | MS 2 | 3,35 | 3,2 |
| 21-10-2021 03:30 | Houston Dynamo - LA Galaxy | MS 2 | 2,55 | 2,44 |
| 21-10-2021 19:45 | Bodo Glimt - AS Roma | MS 1 | 3,5 | 3,35 |
| 21-10-2021 19:45 | Lazio - Marsilya | MS 2 | 3,55 | 3,4 |
| 21-10-2021 17:30 | FK Napredak Krusevac - Novi Pazar | MS 0 | 3,55 | 3,4 |
| 21-10-2021 19:45 | A. Famagusta - Flora Tall | MS 2 | 3,65 | 3,5 |
| 21-10-2021 04:00 | Real CD Espana - CD Victoria | MS 0 | 4,9 | 4,7 |
| 21-10-2021 19:45 | NS Mura - Rennes | MS 2 | 1,29 | 1,24 |
| 21-10-2021 22:00 | Calcio Lecco 1912 - AC Renate | MS 2 | 2,75 | 2,65 |
| 21-10-2021 22:00 | PSV - Monaco | MS 2 | 2,75 | 2,65 |
| 21-10-2021 22:30 | Wydad - OCS de Safi | MS 1 | 1,68 | 1,62 |
| 21-10-2021 04:00 | Independiente Santa Fe - America Cali | MS 0 | 2,8 | 2,7 |
| 21-10-2021 01:30 | San Luis De Quillota - Santiago Mor | MS 0 | 2,8 | 2,7 |
| 21-10-2021 20:30 | Argentinos J - Colon De Santa Fe | MS 2 | 2,85 | 2,75 |
| 21-10-2021 02:00 | Sportivo Ameliano - Guairena FC | MS 1 | 2,85 | 2,75 |
| 21-10-2021 19:00 | Stomil Ols. - P. Bielsko | MS 0 | 2,95 | 2,85 |
| 21-10-2021 05:00 | Orange Count - San Diego Loyal SC | MS 0 | 2,95 | 2,85 |
| 21-10-2021 02:30 | SOL De Mayo - Deportivo Madryn | MS 2 | 2,55 | 2,47 |
| 21-10-2021 02:30 | Penarol Uru - Torque | MS 0 | 3,2 | 3,1 |
| 21-10-2021 02:30 | DC United - New England Revolution | MS 0 | 3,2 | 3,1 |
| 21-10-2021 02:00 | Paysandu SC PA - Penarol AC AM | MS 1 | 1,31 | 1,27 |
| 21-10-2021 22:00 | Eintracht Frankfurt - Olympiacos | MS 0 | 3,3 | 3,2 |
| 21-10-2021 17:30 | HJK Helsinki - M Tel Aviv | MS 2 | 2,19 | 2,13 |
| 21-10-2021 22:00 | Cluj - AZ Alkmaar | MS 2 | 1,88 | 1,83 |
| 21-10-2021 22:00 | PSV - Monaco | MS 1 | 1,94 | 1,89 |
| 21-10-2021 19:45 | Almeria - Real Sociedad B | MS 1 | 1,38 | 1,35 |
| 21-10-2021 19:45 | Kopenhag - PAOK | MS 1 | 1,89 | 1,85 |
| 21-10-2021 17:00 | Sud America - Cerro Largo FC | MS 2 | 1,99 | 1,95 |
| 21-10-2021 23:00 | At Venezuela - Monagas SC | MS 1 | 2,03 | 1,99 |
| 21-10-2021 22:00 | CD Antofagasta - Un. Espanola | MS 2 | 2,55 | 2,5 |
| 21-10-2021 20:30 | Argentinos J - Colon De Santa Fe | MS 0 | 2,65 | 2,6 |
| 21-10-2021 02:30 | DC United - New England Revolution | MS 2 | 2,7 | 2,65 |
| 21-10-2021 01:30 | San Luis De Quillota - Santiago Mor | MS 2 | 2,7 | 2,65 |
| 21-10-2021 04:00 | Santa Tecla - CD Atletico Marte | MS 1 | 1,63 | 1,6 |
| 21-10-2021 22:00 | Partizan - KAA Gent | MS 2 | 2,75 | 2,7 |
| 21-10-2021 20:00 | Gais - Eskilstuna | MS 1 | 2,22 | 2,18 |
| 21-10-2021 22:00 | Jablonec - Randers | MS 1 | 2,23 | 2,19 |
| 22-10-2021 00:30 | U. Chile - Palestino | MS 0 | 2,9 | 2,85 |
| 21-10-2021 22:00 | Slovan Bratislava - Lincoln Red | MS 1 | 1,16 | 1,14 |
| 21-10-2021 04:00 | New Mexico - San Antonio | MS 0 | 2,9 | 2,85 |
| 21-10-2021 03:00 | Deportivo Toluca - Necaxa | MS 1 | 1,79 | 1,76 |
| 22-10-2021 01:00 | Independient - CA Sarmiento | MS 0 | 3 | 2,95 |
| 21-10-2021 22:45 | New Old Boys - CA Aldosivi | MS 1 | 1,8 | 1,77 |
| 21-10-2021 04:00 | Colorado Rapids - Seattle Sounders | MS 0 | 3 | 2,95 |
| 21-10-2021 03:00 | Everton DV - Huachipato | MS 2 | 3 | 2,95 |
| 21-10-2021 02:30 | Inter Miami CF - Toronto FC | MS 0 | 3 | 2,95 |
| 21-10-2021 19:45 | Ludogorets - Braga | MS 0 | 3,05 | 3 |
| 21-10-2021 04:00 | Santa Tecla - CD Atletico Marte | MS 0 | 3,05 | 3 |
| 21-10-2021 02:30 | FC Cincinnati - Chicago Fire | MS 0 | 3,05 | 3 |
| 21-10-2021 21:30 | CA Progreso - Deportivo Maldonado | MS 0 | 3,1 | 3,05 |
| 21-10-2021 19:45 | Rapid Wien - Dinamo Zagreb | MS 0 | 3,1 | 3,05 |
| 21-10-2021 03:30 | Houston Dynamo - LA Galaxy | MS 0 | 3,1 | 3,05 |
| 21-10-2021 03:00 | Deportivo Toluca - Necaxa | MS 0 | 3,1 | 3,05 |
| 21-10-2021 22:00 | CD Antofagasta - Un. Espanola | MS 0 | 3,15 | 3,1 |
| 21-10-2021 22:30 | Wydad - OCS de Safi | MS 0 | 3,2 | 3,15 |
| 21-10-2021 05:00 | Managua FC - Sebaco FC | MS 1 | 1,28 | 1,26 |
| 21-10-2021 14:15 | Persik Kediri - Persipura J | MS 2 | 1,94 | 1,91 |
| 21-10-2021 22:00 | Sparta Prag - Lyon | MS 0 | 3,25 | 3,2 |
| 21-10-2021 19:45 | Real Betis - B. Leverkusen | MS 0 | 3,25 | 3,2 |
| 21-10-2021 19:45 | Lazio - Marsilya | MS 0 | 3,25 | 3,2 |
| 21-10-2021 17:15 | AL Ittihad Kalba - Al Urooba UAE | MS 0 | 3,45 | 3,4 |
| 21-10-2021 03:00 | Club Leon - Pumas Unam | MS 0 | 3,45 | 3,4 |
| 21-10-2021 22:00 | Sturm Graz - Real Sociedad | MS 0 | 3,55 | 3,5 |
| 21-10-2021 02:30 | Botafogo RJ - Brusque Sc | MS 1 | 1,43 | 1,41 |
| 22-10-2021 01:00 | Independient - CA Sarmiento | MS 2 | 3,9 | 3,85 |
| 21-10-2021 02:30 | Penarol Uru - Torque | MS 1 | 1,66 | 1,64 |
| 21-10-2021 17:30 | Flekkeroy - Kjelsas | MS 2 | 1,69 | 1,67 |
| 21-10-2021 19:45 | Feyenoord - Union Berlin | MS 1 | 1,95 | 1,93 |
| 21-10-2021 18:00 | AL Aqaba - Al Jazeera | MS 1 | 2,29 | 2,27 |
| 21-10-2021 20:15 | Polonya (K) - Norveç (K) | MS 2 | 1,22 | 1,21 |
| 21-10-2021 18:00 | Arnavutluk (K) - Ermenistan(K) | MS 1 | 1,26 | 1,25 |
| 21-10-2021 18:00 | Ramtha SC - Shabab AL Ordon | MS 1 | 1,38 | 1,37 |
| 21-10-2021 22:00 | Sturm Graz - Real Sociedad | MS 2 | 1,42 | 1,41 |
| 21-10-2021 17:15 | AL Ittihad Kalba - Al Urooba UAE | MS 1 | 1,56 | 1,55 |
| 21-10-2021 19:45 | A. Famagusta - Flora Tall | MS 1 | 1,57 | 1,56 |
| 21-10-2021 19:45 | Lazio - Marsilya | MS 1 | 1,62 | 1,61 |
| 21-10-2021 18:00 | AL Aqaba - Al Jazeera | MS 2 | 2,33 | 2,32 |